It is important to try to keep your print flat before framing: avoid rolling it or having it rolled as this adds complications. The surface of many digital prints is delicate and susceptible to damage, so protect it carefully to avoid irreversible scratching. The first step is to decide how much of the paper/image you wish to see, thinking about any signatures and inscriptions.
When choosing a frame, think about the style, period and feel of the image as well as what you like and what might suit your interior and/or purpose. Remember that larger images are going to need stronger frames to support them. Digital prints are produced in a variety of ways and many factors can influence their permanence: the type and weight of paper, the type and quality of inks, surface coatings, storage and so on.
We would always advise on the use of UV filtering glass or acrylic to avoid fading inks and yellowing paper. If reflections might be a problem, modern anti-reflection glass can eliminate them. Using acrylic will reduce the overall weight of the frame and avoid damage caused by glass breaking.
Not much can be done about damaged digital prints and reprinting is the usual solution, so always make sure you have the file backed up or examine the print carefully when you first acquire it.